The aim of the present investigation is to formulation development and evaluation of pulsatile drug delivery system for Anti-Asthmatic drug of Montelukast sodium. Sodium CMC generally used for super disintegrator, it increased the lag time of pulsatile drug delivery system with decreasing the amount of quantity and increased the amount of quantity of Carbopol 971P was generally used for swelling agent, Eudragit RS PO is an enteric polymer and the pH of that 7.4. The formulations were evaluated for Drug content, in-vitro dissolution study, Disintegration time and lag time. The developed formulations of pulsatile drug delivery system which give the better lag time. From these formulation the optimize formulation F3 provide lag time of rupture of PRTs is 6:10 hr and release drug after rupture of outer coat. So we can conclude that the Formulation F3 give better lag time of rupture.
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